Hormone profile in juvenile systemic lupus erythematosus with previous or current amenorrhea
Identifieur interne : 001717 ( Main/Exploration ); précédent : 001716; suivant : 001718Hormone profile in juvenile systemic lupus erythematosus with previous or current amenorrhea
Auteurs : Clovis A. Silva [Brésil] ; Maria E. J. Deen [Pays-Bas] ; Marilia V. Febrônio [Brésil] ; Sheila K. Oliveira [Brésil] ; Maria T. Terreri [Brésil] ; Silvana B. Sacchetti [Brésil] ; Flavio R. Sztajnbok [Brésil] ; Roberto Marini [Brésil] ; Maria V. Quintero [Brésil] ; Blanca E. Bica [Brésil] ; Rosa M. Pereira [Brésil] ; Eloisa Bonfá [Brésil] ; Virginia P. Ferriani [Brésil] ; Teresa C. Robazzi [Brésil] ; Claudia S. Magalhães [Brésil] ; Maria O. Hilário [Brésil]Source :
- Rheumatology International [ 0172-8172 ] ; 2011-08-01.
Descripteurs français
- Wicri :
- topic : Hormone.
English descriptors
- KwdEn :
Abstract
Abstract: To identify the underlying mechanism of amenorrhea in juvenile systemic lupus erythematosus (JSLE) patients, thirty-five (11.7%) JSLE patients with current or previous amenorrhea were consecutively selected among the 298 post-menarche patients followed in 12 Brazilian pediatric rheumatology centers. Pituitary gonadotrophins [follicle-stimulating hormone (FSH) and luteinizing hormone (LH)] and estradiol were evaluated in 32/35 patients, and prolactin and total testosterone in 29/35 patients. Patient’s medical records were carefully reviewed according to demographic, clinical and therapeutic findings. The mean duration of amenorrhea was 7.2 ± 3.6 months. Low FSH or LH was observed in 7/32 (22%) JSLE patients and normal FSH or LH in 25 (78%). Remarkably, low levels of FSH or LH were associated with higher frequency of current amenorrhea (57% vs. 0%, P = 0.001), higher median disease activity (SLEDAI) and damage (SLICC/ACR-DI) (18 vs. 4, P = 0.011; 2 vs. 0, P = 0.037, respectively) and higher median current dose of prednisone (60 vs. 10 mg/day, P = 0.0001) compared to normal FSH or LH JSLE patients. None of them had decreased ovarian reserve and premature ovarian failure. Six of 29 (21%) patients had high levels of prolactin, and none had current amenorrhea. No correlations were observed between levels of prolactin and SLEDAI, and levels of prolactin and SLICC/ACR-DI scores (Spearman′s coefficient). We have identified that amenorrhea in JSLE is associated with high dose of corticosteroids indicated for active disease due to hypothalamic-pituitary-ovary axis suppression.
Url:
DOI: 10.1007/s00296-010-1389-2
Affiliations:
- Brésil, Pays-Bas
- Bahia, Groningue (province), État de Rio de Janeiro, État de São Paulo
- Campinas, Groningue, São Paulo
- Université d'État de Campinas, Université de São Paulo
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001616
- to stream Istex, to step Curation: 001616
- to stream Istex, to step Checkpoint: 000662
- to stream Main, to step Merge: 001720
- to stream Main, to step Curation: 001717
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hormone profile in juvenile systemic lupus erythematosus with previous or current amenorrhea</title>
<author><name sortKey="Silva, Clovis A" sort="Silva, Clovis A" uniqKey="Silva C" first="Clovis A." last="Silva">Clovis A. Silva</name>
</author>
<author><name sortKey="Deen, Maria E J" sort="Deen, Maria E J" uniqKey="Deen M" first="Maria E. J." last="Deen">Maria E. J. Deen</name>
</author>
<author><name sortKey="Febronio, Marilia V" sort="Febronio, Marilia V" uniqKey="Febronio M" first="Marilia V." last="Febrônio">Marilia V. Febrônio</name>
</author>
<author><name sortKey="Oliveira, Sheila K" sort="Oliveira, Sheila K" uniqKey="Oliveira S" first="Sheila K." last="Oliveira">Sheila K. Oliveira</name>
</author>
<author><name sortKey="Terreri, Maria T" sort="Terreri, Maria T" uniqKey="Terreri M" first="Maria T." last="Terreri">Maria T. Terreri</name>
</author>
<author><name sortKey="Sacchetti, Silvana B" sort="Sacchetti, Silvana B" uniqKey="Sacchetti S" first="Silvana B." last="Sacchetti">Silvana B. Sacchetti</name>
</author>
<author><name sortKey="Sztajnbok, Flavio R" sort="Sztajnbok, Flavio R" uniqKey="Sztajnbok F" first="Flavio R." last="Sztajnbok">Flavio R. Sztajnbok</name>
</author>
<author><name sortKey="Marini, Roberto" sort="Marini, Roberto" uniqKey="Marini R" first="Roberto" last="Marini">Roberto Marini</name>
</author>
<author><name sortKey="Quintero, Maria V" sort="Quintero, Maria V" uniqKey="Quintero M" first="Maria V." last="Quintero">Maria V. Quintero</name>
</author>
<author><name sortKey="Bica, Blanca E" sort="Bica, Blanca E" uniqKey="Bica B" first="Blanca E." last="Bica">Blanca E. Bica</name>
</author>
<author><name sortKey="Pereira, Rosa M" sort="Pereira, Rosa M" uniqKey="Pereira R" first="Rosa M." last="Pereira">Rosa M. Pereira</name>
</author>
<author><name sortKey="Bonfa, Eloisa" sort="Bonfa, Eloisa" uniqKey="Bonfa E" first="Eloisa" last="Bonfá">Eloisa Bonfá</name>
</author>
<author><name sortKey="Ferriani, Virginia P" sort="Ferriani, Virginia P" uniqKey="Ferriani V" first="Virginia P." last="Ferriani">Virginia P. Ferriani</name>
</author>
<author><name sortKey="Robazzi, Teresa C" sort="Robazzi, Teresa C" uniqKey="Robazzi T" first="Teresa C." last="Robazzi">Teresa C. Robazzi</name>
</author>
<author><name sortKey="Magalhaes, Claudia S" sort="Magalhaes, Claudia S" uniqKey="Magalhaes C" first="Claudia S." last="Magalhães">Claudia S. Magalhães</name>
</author>
<author><name sortKey="Hilario, Maria O" sort="Hilario, Maria O" uniqKey="Hilario M" first="Maria O." last="Hilário">Maria O. Hilário</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:52BEA696A08686F9B7B630CC38F4FCB5404D0ABB</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1007/s00296-010-1389-2</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-L4H3C854-K/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001616</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001616</idno>
<idno type="wicri:Area/Istex/Curation">001616</idno>
<idno type="wicri:Area/Istex/Checkpoint">000662</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000662</idno>
<idno type="wicri:doubleKey">0172-8172:2010:Silva C:hormone:profile:in</idno>
<idno type="wicri:Area/Main/Merge">001720</idno>
<idno type="wicri:Area/Main/Curation">001717</idno>
<idno type="wicri:Area/Main/Exploration">001717</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Hormone profile in juvenile systemic lupus erythematosus with previous or current amenorrhea</title>
<author><name sortKey="Silva, Clovis A" sort="Silva, Clovis A" uniqKey="Silva C" first="Clovis A." last="Silva">Clovis A. Silva</name>
<affiliation wicri:level="4"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Instituto da Criança and Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Rua Araioses, 151/82, Vila Madalena, 05442-010, São Paulo, SP</wicri:regionArea>
<placeName><region type="state">État de São Paulo</region>
<settlement type="city">São Paulo</settlement>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Brésil</country>
</affiliation>
</author>
<author><name sortKey="Deen, Maria E J" sort="Deen, Maria E J" uniqKey="Deen M" first="Maria E. J." last="Deen">Maria E. J. Deen</name>
<affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Rijks Universiteit Groningen, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Febronio, Marilia V" sort="Febronio, Marilia V" uniqKey="Febronio M" first="Marilia V." last="Febrônio">Marilia V. Febrônio</name>
<affiliation wicri:level="4"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Instituto da Criança and Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Rua Araioses, 151/82, Vila Madalena, 05442-010, São Paulo, SP</wicri:regionArea>
<placeName><region type="state">État de São Paulo</region>
<settlement type="city">São Paulo</settlement>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
</author>
<author><name sortKey="Oliveira, Sheila K" sort="Oliveira, Sheila K" uniqKey="Oliveira S" first="Sheila K." last="Oliveira">Sheila K. Oliveira</name>
<affiliation wicri:level="2"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea>
<placeName><region type="state">État de Rio de Janeiro</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Terreri, Maria T" sort="Terreri, Maria T" uniqKey="Terreri M" first="Maria T." last="Terreri">Maria T. Terreri</name>
<affiliation wicri:level="2"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Service, Universidade Federal de São Paulo, São Paulo, SP</wicri:regionArea>
<placeName><region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sacchetti, Silvana B" sort="Sacchetti, Silvana B" uniqKey="Sacchetti S" first="Silvana B." last="Sacchetti">Silvana B. Sacchetti</name>
<affiliation wicri:level="2"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Santa Casa de São Paulo, São Paulo, SP</wicri:regionArea>
<placeName><region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sztajnbok, Flavio R" sort="Sztajnbok, Flavio R" uniqKey="Sztajnbok F" first="Flavio R." last="Sztajnbok">Flavio R. Sztajnbok</name>
<affiliation wicri:level="2"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea>
<placeName><region type="state">État de Rio de Janeiro</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marini, Roberto" sort="Marini, Roberto" uniqKey="Marini R" first="Roberto" last="Marini">Roberto Marini</name>
<affiliation wicri:level="4"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Universidade Estadual de Campinas, Campinas, SP</wicri:regionArea>
<placeName><region type="state">État de São Paulo</region>
<settlement type="city">Campinas</settlement>
</placeName>
<orgName type="university">Université d'État de Campinas</orgName>
</affiliation>
</author>
<author><name sortKey="Quintero, Maria V" sort="Quintero, Maria V" uniqKey="Quintero M" first="Maria V." last="Quintero">Maria V. Quintero</name>
<affiliation wicri:level="2"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Santa Casa de Belo Horizonte, Belo Horizonte, RJ</wicri:regionArea>
<placeName><region type="state">État de Rio de Janeiro</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bica, Blanca E" sort="Bica, Blanca E" uniqKey="Bica B" first="Blanca E." last="Bica">Blanca E. Bica</name>
<affiliation wicri:level="2"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Division of Rheumatology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea>
<placeName><region type="state">État de Rio de Janeiro</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pereira, Rosa M" sort="Pereira, Rosa M" uniqKey="Pereira R" first="Rosa M." last="Pereira">Rosa M. Pereira</name>
<affiliation wicri:level="4"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP</wicri:regionArea>
<placeName><region type="state">État de São Paulo</region>
<settlement type="city">São Paulo</settlement>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
</author>
<author><name sortKey="Bonfa, Eloisa" sort="Bonfa, Eloisa" uniqKey="Bonfa E" first="Eloisa" last="Bonfá">Eloisa Bonfá</name>
<affiliation wicri:level="4"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP</wicri:regionArea>
<placeName><region type="state">État de São Paulo</region>
<settlement type="city">São Paulo</settlement>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
</author>
<author><name sortKey="Ferriani, Virginia P" sort="Ferriani, Virginia P" uniqKey="Ferriani V" first="Virginia P." last="Ferriani">Virginia P. Ferriani</name>
<affiliation wicri:level="4"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Universidade de São Paulo, Ribeirão Preto, SP</wicri:regionArea>
<placeName><region type="state">État de São Paulo</region>
<settlement type="city">São Paulo</settlement>
</placeName>
<orgName type="university">Université de São Paulo</orgName>
</affiliation>
</author>
<author><name sortKey="Robazzi, Teresa C" sort="Robazzi, Teresa C" uniqKey="Robazzi T" first="Teresa C." last="Robazzi">Teresa C. Robazzi</name>
<affiliation wicri:level="2"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Hospital São Rafael, Salvador, BA</wicri:regionArea>
<placeName><region type="state">Bahia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Magalhaes, Claudia S" sort="Magalhaes, Claudia S" uniqKey="Magalhaes C" first="Claudia S." last="Magalhães">Claudia S. Magalhães</name>
<affiliation wicri:level="2"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Universidade Estadual Paulista, Botucatu, SP</wicri:regionArea>
<placeName><region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hilario, Maria O" sort="Hilario, Maria O" uniqKey="Hilario M" first="Maria O." last="Hilário">Maria O. Hilário</name>
<affiliation wicri:level="2"><country xml:lang="fr">Brésil</country>
<wicri:regionArea>Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, SP</wicri:regionArea>
<placeName><region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Rheumatology International</title>
<title level="j" type="sub">Clinical and Experimental Investigations</title>
<title level="j" type="abbrev">Rheumatol Int</title>
<idno type="ISSN">0172-8172</idno>
<idno type="eISSN">1437-160X</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="2011-08-01">2011-08-01</date>
<biblScope unit="volume">31</biblScope>
<biblScope unit="issue">8</biblScope>
<biblScope unit="page" from="1037">1037</biblScope>
<biblScope unit="page" to="1043">1043</biblScope>
</imprint>
<idno type="ISSN">0172-8172</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0172-8172</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Amenorrhea</term>
<term>Gonadal function</term>
<term>Hormone</term>
<term>Juvenile systemic lupus erythematosus</term>
<term>Prednisone</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Hormone</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: To identify the underlying mechanism of amenorrhea in juvenile systemic lupus erythematosus (JSLE) patients, thirty-five (11.7%) JSLE patients with current or previous amenorrhea were consecutively selected among the 298 post-menarche patients followed in 12 Brazilian pediatric rheumatology centers. Pituitary gonadotrophins [follicle-stimulating hormone (FSH) and luteinizing hormone (LH)] and estradiol were evaluated in 32/35 patients, and prolactin and total testosterone in 29/35 patients. Patient’s medical records were carefully reviewed according to demographic, clinical and therapeutic findings. The mean duration of amenorrhea was 7.2 ± 3.6 months. Low FSH or LH was observed in 7/32 (22%) JSLE patients and normal FSH or LH in 25 (78%). Remarkably, low levels of FSH or LH were associated with higher frequency of current amenorrhea (57% vs. 0%, P = 0.001), higher median disease activity (SLEDAI) and damage (SLICC/ACR-DI) (18 vs. 4, P = 0.011; 2 vs. 0, P = 0.037, respectively) and higher median current dose of prednisone (60 vs. 10 mg/day, P = 0.0001) compared to normal FSH or LH JSLE patients. None of them had decreased ovarian reserve and premature ovarian failure. Six of 29 (21%) patients had high levels of prolactin, and none had current amenorrhea. No correlations were observed between levels of prolactin and SLEDAI, and levels of prolactin and SLICC/ACR-DI scores (Spearman′s coefficient). We have identified that amenorrhea in JSLE is associated with high dose of corticosteroids indicated for active disease due to hypothalamic-pituitary-ovary axis suppression.</div>
</front>
</TEI>
<affiliations><list><country><li>Brésil</li>
<li>Pays-Bas</li>
</country>
<region><li>Bahia</li>
<li>Groningue (province)</li>
<li>État de Rio de Janeiro</li>
<li>État de São Paulo</li>
</region>
<settlement><li>Campinas</li>
<li>Groningue</li>
<li>São Paulo</li>
</settlement>
<orgName><li>Université d'État de Campinas</li>
<li>Université de São Paulo</li>
</orgName>
</list>
<tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Silva, Clovis A" sort="Silva, Clovis A" uniqKey="Silva C" first="Clovis A." last="Silva">Clovis A. Silva</name>
</region>
<name sortKey="Bica, Blanca E" sort="Bica, Blanca E" uniqKey="Bica B" first="Blanca E." last="Bica">Blanca E. Bica</name>
<name sortKey="Bonfa, Eloisa" sort="Bonfa, Eloisa" uniqKey="Bonfa E" first="Eloisa" last="Bonfá">Eloisa Bonfá</name>
<name sortKey="Febronio, Marilia V" sort="Febronio, Marilia V" uniqKey="Febronio M" first="Marilia V." last="Febrônio">Marilia V. Febrônio</name>
<name sortKey="Ferriani, Virginia P" sort="Ferriani, Virginia P" uniqKey="Ferriani V" first="Virginia P." last="Ferriani">Virginia P. Ferriani</name>
<name sortKey="Hilario, Maria O" sort="Hilario, Maria O" uniqKey="Hilario M" first="Maria O." last="Hilário">Maria O. Hilário</name>
<name sortKey="Magalhaes, Claudia S" sort="Magalhaes, Claudia S" uniqKey="Magalhaes C" first="Claudia S." last="Magalhães">Claudia S. Magalhães</name>
<name sortKey="Marini, Roberto" sort="Marini, Roberto" uniqKey="Marini R" first="Roberto" last="Marini">Roberto Marini</name>
<name sortKey="Oliveira, Sheila K" sort="Oliveira, Sheila K" uniqKey="Oliveira S" first="Sheila K." last="Oliveira">Sheila K. Oliveira</name>
<name sortKey="Pereira, Rosa M" sort="Pereira, Rosa M" uniqKey="Pereira R" first="Rosa M." last="Pereira">Rosa M. Pereira</name>
<name sortKey="Quintero, Maria V" sort="Quintero, Maria V" uniqKey="Quintero M" first="Maria V." last="Quintero">Maria V. Quintero</name>
<name sortKey="Robazzi, Teresa C" sort="Robazzi, Teresa C" uniqKey="Robazzi T" first="Teresa C." last="Robazzi">Teresa C. Robazzi</name>
<name sortKey="Sacchetti, Silvana B" sort="Sacchetti, Silvana B" uniqKey="Sacchetti S" first="Silvana B." last="Sacchetti">Silvana B. Sacchetti</name>
<name sortKey="Silva, Clovis A" sort="Silva, Clovis A" uniqKey="Silva C" first="Clovis A." last="Silva">Clovis A. Silva</name>
<name sortKey="Sztajnbok, Flavio R" sort="Sztajnbok, Flavio R" uniqKey="Sztajnbok F" first="Flavio R." last="Sztajnbok">Flavio R. Sztajnbok</name>
<name sortKey="Terreri, Maria T" sort="Terreri, Maria T" uniqKey="Terreri M" first="Maria T." last="Terreri">Maria T. Terreri</name>
</country>
<country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Deen, Maria E J" sort="Deen, Maria E J" uniqKey="Deen M" first="Maria E. J." last="Deen">Maria E. J. Deen</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001717 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001717 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:52BEA696A08686F9B7B630CC38F4FCB5404D0ABB |texte= Hormone profile in juvenile systemic lupus erythematosus with previous or current amenorrhea }}
This area was generated with Dilib version V0.6.33. |